Manciano is located on a hill between the sea and the mountains, guarding the Maremma. The location allows for a privileged view of the Maremma with a view stretching to the sea of Amiata, which is what gave it such strategic importance throughout history. At the highest point of the village stands the castle, around which the town center has grown like a labyrinth in the intriguing shape of a fan. The village is a maze of up and downhill streets which all lead to the Piazza Magenta: the panoramic views of the Piazza, the Castle and the newly renovated and interactive Museum of Prehistory and Early History will make this visit one to remember.

Manciano is home to two famous artists: Pietro Aldi and Paride Pascucci, the painters who symbolize the culutre of the Maremma. Some important works of these two artists are visible inside the castle, the Church of San Leonardo and the SS.Annunziata.